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Industrial Scale Suspension Culture of Living Cells

  • Erscheinungsdatum: 30.07.2014
  • Verlag: Wiley-Blackwell
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Industrial Scale Suspension Culture of Living Cells

The submersed cultivation of organisms in sterile containments or fermenters has become the standard manufacturing procedure, and will remain the gold standard for some time to come. This book thus addresses submersed cell culture and fermentation and its importance for the manufacturing industry. It goes beyond expression systems and integrally investigates all those factors relevant for manufacturing using suspension cultures. In so doing, the contributions cover all industrial cultivation methods in a comprehensive and comparative manner, with most of the authors coming from the industry itself. Depending on the maturity of the technology, the chapters address in turn the expression system, basic process design, key factors affecting process economics, plant and bioreactor design, and regulatory aspects. The holder of a PhD in microbiology from the University of Fribourg, Switzerland, Hans-Peter Meyer served as VP Strategic Projects Biotechnology at Lonza until his retirement in early 2014. Following three years of postdoctoral studies in Stockholm, at the University of Pennsylvania, Philadelphia, and Lehigh University, Bethlehem, USA, in 1982 he joined Prof. Armin Fiechter's team as group leader at the ETH in Zürich before starting at Lonza in Visp, Switzerland in 1986, where he held a number of positions in R&D, manufacturing, and sales & marketing. He recently joined the faculty of the University of Applied Sciences and Arts of Western Switzerland, and also remains an expert at the Commission for Technology & Innovation (CTI) of the Swiss Federal Confederation. Diego R. Schmidhalter is head of R&T within the pharma and biotechnology custom manufacturing division at Lonza Switzerland. He holds a PhD in microbiology from the University of Fribourg, Switzerland, and carried out two years of postdoctoral studies at Genencor International, California, USA. He has held various management positions at Lonza, including head of microbial manufacturing, head of the Biopharma R&D Services business, and as head of Microbial Manufacturing Science and Technology, as well as being a member of the Biopharmaceuticals business team. Dr. Schmidhalter has over 20 years of experience in the biotechnology industry in biopharmaceuticals and biochemicals process development and manufacturing, technology transfer, scaling-up fermentations right up to the 50,000-liter scale, and within the biopharmaceuticals related regulatory environment.

Produktinformationen

    Format: ePUB
    Kopierschutz: AdobeDRM
    Seitenzahl: 450
    Erscheinungsdatum: 30.07.2014
    Sprache: Englisch
    ISBN: 9783527683352
    Verlag: Wiley-Blackwell
    Größe: 9570 kBytes
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Industrial Scale Suspension Culture of Living Cells

List of Contributors

Patrick Aebischer

President of EPFL

École Polytechnique Fédérale de

Lausanne

Centre Est, Station 1

1015 Lausanne

Switzerland

Richard M. Alldread

National Biologics Manufacturing Centre

Centre for Process Innovation (CPI)

Wilton Centre, Wilton

Redcar

Cleveland, TS10 4RF

UK

Paula Alves

ITQB-UNL

Av. Repú;blica-EAN

2780-157 Oeiras

Portugal

and

IBET

Apartado 12

2781-901 Oeiras

Portugal

Wilfried A.M. Bakker

Intravacc – Institute for Translational Vaccinology

Antonie van Leeuwenhoeklaan 9

Bilthoven, 3721 MA

The Netherlands

P. Noel Barrett

Baxter Bioscience

Vaccine R&D

Uferstrasse 15

2304 Orth/Donau

Vienna

Austria

Peter Bergmann

Environmental Biotechnology and Bioprocess Engineering

Subitec GmbH

Julius-Hölder-Str. 36

70597 Stuttgart

Germany

Lars Beyer

Subitec GmbH

Julius-Hölder-Str. 36

70597 Stuttgart

Germany

John R. Birch

Henley-on-Thames

UK

Reinhard Breitling

Jena Bioscience GmbH

Loebstedter Str. 80

07749 Jena

Germany

Aude Carlier

Algenics

Pôle Bio Ouest

rue du Moulin de la Rousselière

44800 Saint-Herblain

France

Manuel Carrondo

IBET

Apartado 12

2781-901 Oeiras

Portugal

and

FCT-UNL

Campus Universitário

2829-516 Caparica

Portugal

Manon Cox

Protein Sciences Corporation

1000 Research Parkway

Meriden, CT 06450

USA

Michal Dabros

University of Applied Sciences and Arts Western Switzerland

College of Engineering and Architecture of Fribourg

Bd de Pérolles 80

1705 Fribourg

Switzerland

Paulina Dabrowska-Schlepp

greenovation Biotech GmbH

Hans-Bunte-Strasse 19

79108 Freiburg

Germany

Dieter Eibl

Zurich University of Applied Sciences

Institute of Biotechnology

Group of Biochemical Engineering and Cell Cultivation Techniques

Campus Grüental

8820 Wädenswil

Switzerland

Regine Eibl

Zurich University of Applied Sciences

Institute of Biotechnology

Group of Biochemical Engineering and Cell Cultivation Techniques

Campus Grüental

8820 Wädenswil

Switzerland

Suzanne Farid

University College London

Advanced Centre for Biochemical Engineering

Department of Biochemical Engineering

Torrington Place

London WC1E 7JE

UK

Krist V. Gernaey

Technical University of Denmark

Department of Chemical and Biochemical Engineering

Center for Process Engineering and Technology

Søltofts Plads 229

2800 Lyngby

Denmark

Gilbert Gorr

Phyton Biotech® GmbH

Alter Postweg 1

22926 Ahrensburg

Germany

Marcus W.W. Hartmann

Cilian AG

Johann-Krane Weg 42

48149 Münster

Germany

Christoph Herwig

Vienna University of Technology

Institute of Chemical Engineering

Gumpendorferstraße 1a

1060 Vienna

Austria

Nicole Imseng

Zurich University of Applied Sciences

Institute of Biotechnology

Group of Biochemical Engin

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