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Antitargets and Drug Safety

  • Erscheinungsdatum: 23.02.2015
  • Verlag: Wiley-VCH
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Antitargets and Drug Safety

With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered. Laszlo Urban received his MD and PhD in neurophysiology/neuropharmacology in Hungary, and was visiting professor at Duke University between 1987 and 1989. He is currently global head of Preclinical Safety Profiling at the Novartis Institutes for Biomedical Research, Cambridge, USA, and was previously the Deputy Head of the Novartis Institute for Medical Sciences in London, UK. Dr. Urban has over 130 scientific articles, book chapters and patents to his name. Roy J. Vaz received his PhD in organic chemistry from the University of Florida, Gainesville, an MBA from the University of Illinois, and most recently an MS in molecular biology from Lehigh University, USA. He is currently a senior distinguished scientist at Sanofi Pharmaceuticals in Waltham, MA, and was previously Director of the Investigative Product Optimization department under Aventis. He has worked at Bristol-Myers Squibb as Principal Scientist as well as at Tripos, Inc, as a research scientist. Dr. Vaz has authored or co-authored around 45 publications in peer-reviewed journals, eight book chapters and several patents. Vinod Patel gained his BSc in applied chemistry from Leicester Polytechnic, and a PhD in synthetic organic chemistry from Nottingham University, UK. He took up a post-doctoral fellowship at the University of Rochester, NY, USA, before joining Eli Lilly & Company, where he spent the next nine years as a medicinal chemist in the oncology division. He then joined Kinetix Pharmaceuticals, which was acquired by Amgen and Dr. Patel joined their new Cambridge facility as head of medicinal chemistry. In 2011, he joined Sanofi oncology research as head of medicinal chemistry where he is currently head of chemical research in lead generation candidate realization. Dr. Patel has over 50 publications and some 50 patents to his name.

Produktinformationen

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Antitargets and Drug Safety

List of Contributors

Daniel J. Antoine

University of Liverpool

Institute of Translational Medicine

Department of Molecular and Clinical Pharmacology

MRC Centre for Drug Safety Science

Liverpool L69 3GE

UK

Richard J. Brennan

Sanofi US

Preclinical Safety

DSAR

153 2nd Ave.

Waltham, MA 02451

USA

Kim L.R. Brouwer

The University of North Carolina at Chapel Hill

UNC Eshelman School of Pharmacy

Division of Pharmacotherapy and Experimental Therapeutics

Chapel Hill, NC 27599

USA

José S. Duca

Novartis Institutes for BioMedical Research

Computer Assisted Drug Discovery

100 Technology Square

Cambridge, MA 02139

USA

Berengere Dumotier

Novartis Institutes for BioMedical Research

Preclinical Safety/Cardiac Electrophysiology

Klybeckstrasse 141, WKL.136.178

4057 Basel

Switzerland

Gül Erdemli

Novartis Institutes for BioMedical Research

Center for Proteomic Chemistry

Ion Channel Group

250 Massachusetts Ave.

Cambridge, MA 02139

USA

Ramy Farid

Schrödinger, Inc.

120 West Forty-Fifth Street, 17th Floor

New York, NY 10036

USA

Alexander Fekete

Novartis Institutes for BioMedical Research

Preclinical Safety

Preclinical Secondary Pharmacology

250 Massachusetts Avenue

Cambridge, MA 02139

USA

Oliver Flint

Bristol-Myers Squibb

Pharmaceutical Candidate

Optimization

Discovery Toxicology

Liberty Drive

Newtown, PA 18940

USA

Gary Gintant

AbbVie

Integrated Science and Technology

Department of Integrative Pharmacology

Abbott Park Road

Abbott Park, IL 60064

USA

Andrea Greiter-Wilke

F. Hoffmann-La Roche Ltd.

Pharmaceuticals/Metabolic DTA

Grenzacherstrasse 124

4070 Basel

Switzerland

Brian Guth

Boehringer Ingelheim Pharma GmbH & Co. KG

General Pharmacology, Drug Discovery Support

Biberach an der Riss

Germany

Robert L. Hamlin

QTest Labs LLC and The Ohio State University

1900 Coffey Road

Columbus, OH 43210

USA

Jacques Hamon

Novartis Institutes for BioMedical Research

Preclinical Safety Profiling

Klybeckstrasse 141

4057 Basel

Switzerland

Andreas Hartmann

Novartis Institutes for BioMedical Research

Preclinical Safety

Klybeckstrasse

4057 Basel

Switzerland

Brett A. Howell

The Hamner Institutes for Health Sciences

The Hamner-UNC Institute for Drug Safety Sciences

Research Triangle Park, NC 27709

USA

Daniel Hoyer

The University of Melbourne

Faculty of Medicine, Dentistry and Health Sciences

School of Medicine

Department of Pharmacology and Therapeutics

Parkville, Victoria 3010

Australia

and

The University of Melbourne

The Florey Institute of Neuroscience and Mental Health

30 Royal Parade

Parkville, Victoria 3052

Australia

and

The Scripps Research Institute

Department of Chemical Physiology

10550 North Torrey Pines Road

La Jolla, CA 92037

USA

Qi-Ying Hu

Novartis Institutes for BioMedical Research

Global Discovery Chemistry

100 Technology Square

Cambridge, MA 02139

USA

Haisong Ju

Novartis Institutes for BioMedical Research Head

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